18F-FDG PET/CT imaging detects therapy efficacy of anti-EMMPRIN antibody and gemcitabine in orthotopic pancreatic tumor xenografts

Academic Article

Abstract

  • Purpose: The objective of this study is to evaluate the therapeutic response to a novel monoclonal antibody targeting human extracellularmatrixmetalloproteinase inducer (EMMPRIN) in combination with gemcitabine in a pancreatic-tumor xenograftmurinemodel by sequential 2-deoxy-2-[18F]fluoro-D-glucose ( 18F-FDG) positron emission tomography/computed tomgraphy (PET/CT) imaging. Procedures: Four groups of SCID mice bearing orthotopic pancreatic tumor xenografts were injected with phosphate-buffered saline, gemcitabine (120 mg/kg BW), anti-EMMPRIN antibody (0.2 mg), or combination, respectively, twice weekly for 2 weeks, while 18F-FDG PET/CT imaging was performed weekly for 3 weeks. Changes in mean standardized uptake value (SUV mean) of 18F-FDG and volume of tumors were determined. Results: The tumor SUV mean change in the group receiving combination therapy was significantly lower than those of the other groups. Tumor-volume changes of groups treated with anti-EMMPRIN monotherapy or combined therapy were significantly lower than that of the control group. Conclusions: These data provide support for clinical studies of anti-EMMPRIN therapy with gemcitabine for pancreatic cancer treatment. © Academy of Molecular Imaging and Society for Molecular Imaging, 2011.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 26730609
  • Author List

  • Shah N; Zhai G; Knowles JA; Stockard CR; Grizzle WE; Fineberg N; Zhou T; Zinn KR; Rosenthal EL; Kim H
  • Start Page

  • 237
  • End Page

  • 244
  • Volume

  • 14
  • Issue

  • 2