Differential role of prostaglandin E1 on tumor metastasis

Academic Article

Abstract

  • Previous studies from our laboratory have shown that intravenous (iv) infusion of pharmacologic doses of prostaglandin E (PGE ) inhibits "spontaneous" metastases in mice bearing Lewis Lung carcinoma (LLC). This study was done to determine the effect of iv PGE on "artificial" metastases. Male hybrid mice (20 g) underwent iv catheterization and were begun on continuous infusions of either PGE at 10 μg/kg/min or 0.9% NaCl (NS). After 2 days, each mouse received an iv injection of 10 viable LLC cells and was continued on the infusion regimens. Pulmonary metastatic nodules were enumerated and measured 12 days after injection. The iv infusion of PGE increased the metastatic rate 6-fold, the number of metastases ≥2 mm in diameter 7-fold, and the number of metastases ≥ 3 mm in diameter 14-fold. Thus, PGE demonstrates differential effects on tumor metastases, acting as a promotor of artificial metastases, in contrast to its antimetastatic effect on an intact primary tumor. When the promotional effect of iv PGE on artificial metastases is evaluated in light of our previous studies, it can be concluded that the inhibitory effect of PGE on spontaneous metastases from an intact tumor is secondary to the effect of PGE at the level of the primary tumor, and not in the circulation or at the target organ of metastases (lung). © 1990. 1 1 1 1 1 1 1 1 1 5
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Ellis LM; Copeland EM; Bland KI; Sitren HS
  • Start Page

  • 333
  • End Page

  • 336
  • Volume

  • 48
  • Issue

  • 4