Longitudinal analysis of mammary cancer multiplicity in chemoprevention studies

Academic Article

Abstract

  • Background: The effect of chemopreventive agents on cancer multiplicity is of primary interest in animal studies. The nature of data collected from chemoprevention studies may be analyzed by a longitudinal analysis of repeatedly measured cancer multiplicity data. Methods: We determined the number of mammary cancers over the entire follow-up period for varying doses of two chemopreventive agents. Longitudinal analyses were performed to model the number of cancers over different time intervals. Results: There was a significant increase in the number of cancers between six to seven weeks post-carcinogen administration in the control group. Varying patterns of cancer development were observed at different doses of chemopreventive agents including a delay in onset of tumor growth compared to the control group. Conclusion: Longitudinal data analysis complements traditional analyses by providing detailed information regarding the effect of chemopreventive agents on the pattern of tumor development throughout the follow-up period. Importantly, some chemopreventive agents may delay time to appearance of mammary cancers without causing a significant difference in cancer multiplicity.
  • Pubmed Id

  • 15646608
  • Author List

  • Weiss HL; Rodríguez-Burford C; Grubbs CJ; Grizzle WE
  • Start Page

  • 2281
  • End Page

  • 2287
  • Volume

  • 20
  • Issue

  • 4