Synthesis and biodistribution of peptide based 99mTc/186Re- MAGIPG-D612 monoclonal antibody in nude mice bearing colon cancer xenografts

Academic Article

Abstract

  • A new bifuncfional chelating agent MAGIPG was synthesized in good yield using Boc-p-nitrophenylalanine as the starting material. 99mTc-labeled- MAGIPG-D612 conjugates reactive with human colon cancer were prepared in 3% to 15% yield with a radiochemical purity of 63% to 97%. 186Re-labeled MAGIPG-D612 conjugates were prepared with a 7% to 30% yield and a radiochemical purity of 82% to 98%. The biodistribution results demonstrate that these radioimmunoconjugates selectively localized in LS174T human colon cancer xenografts.
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    Author List

  • Ram S; Merriwether W; Buchsbaum DJ
  • Start Page

  • 55
  • End Page

  • 62
  • Volume

  • 12
  • Issue

  • 1