The p21-Ras signal transduction pathway and growth regulation in human high-grade gliomas

Academic Article


  • Deregulated p21-Ras function, as a result of mutation, overexpression or growth factor-induced overactivation, contributes to at least 30% of human cancer. This article reviews the potential role of the p21-Ras family of GTPases in the regulation of growth of high-grade gliomas and describes how targeting this oncoprotein clinically may provide a novel strategy to counteract glioma proliferation. The application of strategies directed at selectively opposing the deregulated signal transduction pathway of high- grade gliomas may be of potential therapeutic benefit and may offer a whole new arsenal of antineoplastic agents to be included in the multimodal treatment of these challenging neoplasms.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Bredel M; Pollack IF
  • Start Page

  • 232
  • End Page

  • 249
  • Volume

  • 29
  • Issue

  • 2-3