Gene-protein correlation in single cells

Academic Article


  • We present a novel methodology combining traditional fluorescent in situ hybridization with an in situ protein detection technology called proximity ligation assay. This method has potential to perform a detailed analysis of the relationship between gene status and corresponding protein expression in cells and tissues. We demonstrate that the fluorescent in situ gene protein assay methodology is capable of resolving gene and protein patterns simultaneously on a cell-by-cell basis. © 2011 The Author(s).
  • Published In

  • Neuro-Oncology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Renfrow JJ; Scheck AC; Dhawan NS; Lukac PJ; Vogel H; Chandler JP; Raizer JJ; Harsh GR; Chakravarti A; Bredel M
  • Start Page

  • 880
  • End Page

  • 885
  • Volume

  • 13
  • Issue

  • 8