T lymphocytes infiltrating advanced grades of cervical neoplasia. CD8‐positive cells are recruited to invasion

Academic Article

Abstract

  • Background. Impaired cellular immunity appears to be a risk factor for progression of cervical neoplasia, but the immunobiology of neoplastic progression is poorly understood. The objective of this study was to characterize the subpopulations of T lymphocytes that infiltrate various grades of cervical neoplasia including metaplasia to invasive cancer in immunocompetent women. Method. In 65 patients with a spectrum of cervical disease ranging from normal cytology to carcinoma, the relative proportions of total T lymphocytes and CD4‐ or CD8‐expressing (helper or cytotoxic) T lymphocyte subsets were determined by immunohistochemistry. Results. When the invasive carcinoma stromal infiltrate was compared with the infiltrate of preinvasive lesions, the numbers of total T cells and the CD8‐positive subset increased significantly in the invasive cancers (P < 0.005). Although immunocyte infiltrates were highly concentrated in focal clusters beneath the preinvasive squamous lesions, the CD8‐positive immunocytes diffusely infiltrated the invading tumor. Conclusions. The CD8‐positive T cell infiltrate far exceeded the CD4‐positive cells in the invasive, but not in the preinvasive lesions, a finding that suggests that CD8 cells are recruited preferentially to cervical lesions with progression to invasion. Copyright © 1995 American Cancer Society
  • Published In

  • Cancer  Journal
  • Author List

  • Edwards RP; Kuykendall K; Crowley Nowick P; Partridge EE; Shingleton HM; Mestecky J
  • Start Page

  • 1411
  • End Page

  • 1415
  • Volume

  • 76
  • Issue

  • 8