Lack of association between polymorphism of the human cyclic GMP-dependent protein kinase gene and obesity

Academic Article

Abstract

  • OBJECTIVE: To investigate whether genetic variation in the cyclic CMP-dependent protein kinase gene (PRKC1) is associated with obesity. METHODS: The study included 143 individuals from New York City area, NY, USA. The subjects were sampled on the basis of body mass index (BMI): obese (BMI ranging from 33.8 to 89.5 kg/m2), and nonobese (BMI ranging from 16.0 to 29.4 kg/m2). The association between C2276T polymorphism in PRKG1 gene and obesity was tested using linear regression analysis. RESULTS: BMI levels were predicted by linear regression models adjusted for demographic factors. An analysis was performed twice: in individuals of all ethnical backgrounds and in European-Americans only. In both cases, genotype did not have a significant effect. CONCLUSION: We found no evidence that the C2276T polymorphism in the PKRG1 gene is associated with obesity. © 2005 Nature Publishing Group. All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Zakharkin SO; Belay AT; Fernandez JR; De Luca V; Kennedy JL; Sokolowski MB; Allison DB
  • Start Page

  • 872
  • End Page

  • 874
  • Volume

  • 29
  • Issue

  • 7