HLA-A2, or a closely linked gene, confers susceptibility to early-onset sporadic alzheimer’s disease in mene

Academic Article

Abstract

  • There is a weak association between Alzheimer’s disease (AD) and the histocompatibility antigen HLA-A2, suggesting that A2 has either a minor role in AD or a major role in a subtype of it. To test these alternatives, we studied 54 consecutively ascertained AD patients diagnosed by NINCDS-ADRDA criteria. Patients had a higher frequency of A2 than control subjects, primarily due to the elevated frequency of this antigen in men with early onset of dementia (< 60 years): 92% of early-onset men had A2 as compared with 44% of controls. This finding suggests that A2, or a closely linked gene, confers susceptibility to early-onset AD in men. Furthermore, A2 appears to be primarily associated with sporadic AD, rather than with the familial subtype. © 1991 American Academy of Neurology.
  • Authors

    Published In

  • Neurology  Journal
  • Author List

  • Payami H; Kaye J; Becker W; Norman D; Wetzsteon P
  • Start Page

  • 1544
  • End Page

  • 1548
  • Volume

  • 41
  • Issue

  • 10