Lack of evidence for maternal effect in familial Alzheimer's disease

Academic Article


  • Mitochondrial defects may be involved in Alzheimer's disease (AD) by lowering the oxidative phosphorylation efficiency at an earlier age. To investigate the possible contribution of an inherited mitochondrial DNA defect to familial AD (FAD), we examined the Genetic Analysis Workshop (GAW) data for evidence of maternal transmission and the effect on the age of onset. We found no evidence in support of inherited mitochondrial defects in the GAW FAD kindreds. © 1993 Wiley‐Liss, Inc. Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Payami H; Hoffbuhr K
  • Start Page

  • 461
  • End Page

  • 464
  • Volume

  • 10
  • Issue

  • 6