HLA-A2 homozygosity but not heterozygosity is associated with Alzheimer disease

Academic Article


  • AD is associated with the A2 allele of the human leukocyte antigen (HLA). However, it is not currently known whether there is any difference between A2 homozygotes and A2 heterozygotes. The authors studied 458 patients with AD and found that A2 homozygotes had earlier onset of AD than either A2 heterozygotes (5.4 years, p = 0.002) or those without A2 (5.2 years, p = 0.003). The "recessive" nature of this association suggests that loss of function at the HLA-A locus or a closely linked gene is associated with AD.
  • Authors

    Published In

  • Neurology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Zareparsi S; James DM; Kaye JA; Bird TD; Schellenberg GD; Payami H
  • Start Page

  • 973
  • End Page

  • 975
  • Volume

  • 58
  • Issue

  • 6