DBH is a candidate gene in Parkinson's disease (PD) and contains a putative functional polymorphism (-1021C→T) that has been reported to modify PD susceptibility. We examined -1021C→T in a sample of 1,244 PD patients and 1,186 unrelated control subjects. There was no significant difference in allele (p = 0.14) or genotype (p = 0.26) frequencies between the two groups. A similar result was obtained after pooling our data with those previously published. Furthermore, we found no evidence for an effect of genotype on age at onset among patients. Our findings argue against DBH -1021C→T as a risk factor or age at onset modifier in PD. © 2007 American Neurological Association Published by Wiley-Liss, Inc., through Wiley Subscription Services.