Neoplasms of the central nervous system: Epidemiologic considerations

Academic Article


  • Incidence rates were computed for central nervous system neoplasms for the resident population of Rochester, Minn., for the thirty-four-year period 1935 through 1968. The records of the Mayo Clinic were the major source of data for the cases; the ancillary records in other medical facilities in and near Rochester could be identified and were available through the expanded diagnostic index of the Rochester epidemiology program. There were 174 primary and 123 metastatic CNS neoplasms. Ninety-five percent of the primary brain and spinal cord neoplasms were histologically confirmed. During the study period, 36% of the primary CNS neoplasms were first diagnosed at autopsy. Meningiomas accounted for more than one-half of this group. Average annual incidence rates per 100,000 population were 12.5 for primary brain neoplasms, 1.9 for pituitary neoplasms, 1.3 for primary spinal cord neo plasms, and 11.1 for metastases to the CNS. No consistent trend over time was observed in the incidence rates for meningiomas, gliomas, or all primary CNS tumors combined. Age-specific incidence rates for primary brain neoplasms increased significantly with age; the rates for pituitary and spinal cord neoplasms showed a trend toward increase with age. No sex predilection could be found for primary brain, pituitary, or spinal cord or metastatic tumors. Meningiomas were found significantly more frequently in females. Five-year survival, determined by the direct method, was 22% for gliomas and 59% for meningiomas. © 1972 American Academy of Neurology.
  • Authors

    Published In

  • Neurology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Percy AK; Elveback LR; Okazaki H; Kurland LT
  • Start Page

  • 40
  • End Page

  • 48
  • Volume

  • 22
  • Issue

  • 1