Krabbe disease: Specific MRI and CT findings

Academic Article


  • In three patients with Krabbe disease (galactosylceramide lipidosis), CT and MRI patterns progressed with the evolution of the disease. At first, discrete and symmetric dense areas on CT were found in deep gray matter of hemispheres and brainstem, and also in periventricular and capsulai white matter. MRI showed decreased Tl values with normal or slightly decreased T2 values in those areas and large symmetric “plaque-like” lesions with high Tl and T2 values in white matter of the centrum semiovale. Later, both CT and MRI revealed diffuse reduction in gray matter and, more profoundly, in white matter mass. These findings may alert clinicians to the possibility of Krabbe disease in infants with progressive encephalopathy. © 1986 American Academy of Neurology.
  • Authors

    Published In

  • Neurology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Baram TZ; Goldman AM; Percy AK
  • Start Page

  • 111
  • End Page

  • 115
  • Volume

  • 36
  • Issue

  • 1