Inhibitory effects of cocaine on NGF-induced neuronal differentiation: Incomplete reversibility after a critical time period

Academic Article


  • We extend our findings showing dose-dependent cocaine inhibition of differentiation in NGF-stimulated PC-12 cells without affecting cell viability by demonstrating that neurite extension is severely limited after 24 h, maximal effect is reached at 36 h and recovery is only partial. Cocaine metabolites lack-these effects. A similar process may occur following human prenatal exposure, perhaps through cocaine-induced changes in gene expression or other intracellular signalling events.
  • Authors

    Published In

  • Brain Research  Journal
  • Digital Object Identifier (doi)

    Author List

  • Zachor DA; Moore JF; Smoot TM; Percy AK
  • Start Page

  • 270
  • End Page

  • 272
  • Volume

  • 729
  • Issue

  • 2