Decreased cerebrospinal fluid levels of β-phenylethylamine in patients with Rett syndrome

Academic Article

Abstract

  • To clarify the mechanism of brain impairment in Rett syndrome, we measured the cerebrospinal fluid levels of β-phenylethylamine (PEA) in 17 patients with Rett syndrome. Findings were compared with those obtained in age-matched controls and diseased controls. The cerebrospinal fluid level of PEA was significantly lower in patients with Rett syndrome than in the controls (31% of control values). The alteration in the cerebrospinal fluid level of PEA may reflect dopamine system impairment in Rett syndrome.
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    Author List

  • Satoi M; Matsuishi T; Yamada S; Yamashita Y; Ohtaki E; Mori K; Riikonen R; Kato H; Percy AK
  • Start Page

  • 801
  • End Page

  • 803
  • Volume

  • 47
  • Issue

  • 6