Evaluation of multiple drug therapy in human immunodeficiency virus-infected pediatric patients.

Academic Article

Abstract

  • BACKGROUND: An aggressive therapeutic approach for treatment of HIV in adults consists of combining five or more concurrent antiretrovirals. The clinical benefits of this regimen are often accompanied by increased toxicities. We report the safety and tolerance of multiple drug therapy in HIV-infected children. METHODS: A retrospective chart review was performed to identify HIV-infected children who received > or =5 concurrent antiretrovirals or 4 antiretrovirals plus hydroxyurea. Treatment success was defined as > or =1 log(10) decrease in plasma HIV RNA from baseline any time during multiple drug therapy. Toxicities were defined as a >Grade 2 change from baseline in laboratory values. RESULTS: Twelve patients received multiple drug therapy for 6 months, and 42% of patients continued to receive therapy for at least 1 year. No Grade 3 or 4 toxicities or laboratory abnormalities were reported. Treatment success occurred in 8 (83%) of 12 patients. Adherence was a determining factor in treatment success or failure. CONCLUSIONS: Treatment of HIV-infected children with multiple drug therapy was well-tolerated in this cohort. Treatment success occurred in most patients, with adherence affecting patients' likelihood of success. Larger controlled clinical trials in this patient population are necessary to determine whether the benefit of this therapeutic approach outweighs potential risks.
  • Keywords

  • Adolescent, Adult, Anti-HIV Agents, Antiretroviral Therapy, Highly Active, Child, Child, Preschool, Cohort Studies, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Therapy, Combination, Female, Follow-Up Studies, HIV Infections, Humans, Infant, Male, Maximum Tolerated Dose, Retrospective Studies, Risk Assessment, Severity of Illness Index, Survival Rate, Treatment Outcome
  • Digital Object Identifier (doi)

    Author List

  • King JR; Acosta EP; Chadwick E; Yogev R; Crain M; Pass R; Kimberlin DW; Sturdevant MS; Aldrovandi GM
  • Start Page

  • 239
  • End Page

  • 244
  • Volume

  • 22
  • Issue

  • 3