Human cytomegalovirus virion-associated protein with kinase activity

Academic Article


  • Protein kinase activity was detected in immunoprecipitates of human cytomegalovirus virions and infected cells by using a monoclonal antibody directed against an abundant 68,000-dalton virion structural protein. Purification of this protein by electrophoresis confirmed that the kinase activity was associated with this protein. The kinase activity was dependent on divalent cations (Mg2+, Mn2+) and cyclic nucleotide independent and exhibited optimal activity at pH 7 to 8. The kinase phosphorylated threonine and serine but not tyrosine.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Britt WJ; Auger D
  • Start Page

  • 185
  • End Page

  • 188
  • Volume

  • 59
  • Issue

  • 1