Postattachment events associated with viral entry are necessary for induction of interferon-stimulated genes by human cytomegalovirus

Academic Article

Abstract

  • Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results indicate that ISG induction does not occur when virion-mediated, post-high-affinity attachment events are inhibited by either reagent. Thus, virion-mediated postattachment events, such as fusion, are required for ISG induction.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Netterwald JR; Jones TR; Britt WJ; Yang SJ; McCrone IP; Zhu H
  • Start Page

  • 6688
  • End Page

  • 6691
  • Volume

  • 78
  • Issue

  • 12