Low antibody-dependent cellular cytotoxicity responses in Zambians prior to HIV-1 intrasubtype C superinfection

Academic Article

Abstract

  • We have previously shown that HIV-1 superinfected Zambian seroconverters mount low binding and neutralizing antibody responses to their primary HIV-1 infecting virus, which could increase susceptibility to re-infection. Here, we investigated if antibody-dependent cellular cytotoxicity (ADCC), a process by which virus-infected cells are killed, was also reduced. Superinfected individuals exhibited low ADCC activity compared to non-superinfected individuals, but similar levels of CMV-reactive binding antibodies, suggesting superinfected individuals are capable of generating and maintaining virus-specific antibodies. © 2014 Elsevier Inc.
  • Published In

  • Virology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Basu D; Xiao P; Ende Z; Bere A; Britt WJ; Mulenga J; Kilembe W; Allen SA; Derdeyn CA; Hunter E
  • Start Page

  • 295
  • End Page

  • 298
  • Volume

  • 462-463
  • Issue

  • 1