Diagnostic consequences of cytomegalovirus glycoprotein B polymorphisms

Academic Article

Abstract

  • Failure of a cytomegalovirus (CMV) real-time PCR assay targeting glycoprotein B (gB) was investigated. A multiplex assay targeting gB and immediate-early 2 (IE2) genes showed discordant results (gB negative and IE positive or a >10-fold-higher viral load with IE primers) in saliva from 14.6% of CMV-infected newborns. Sequencing revealed 3 patterns of gB variations. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Novak Z; Chowdhury N; Ross SA; Pati SK; Fowler K; Boppana SB
  • Start Page

  • 3033
  • End Page

  • 3035
  • Volume

  • 49
  • Issue

  • 8