Modulation of the mevalonate pathway by AKT regulates macrophage survival and development of pulmonary fibrosis

Academic Article

Abstract

  • Protein kinase B (Akt) is a key effector of multiple cellular processes, including cell survival. Akt, a serine/threonine kinase, is known to increase cell survival by regulation of the intrinsic pathway for apoptosis. In this study, we found that Akt modulated the mevalonate pathway, which is also linked to cell survival, by increasing Rho GTPase activation. Akt modulated the pathway by phosphorylating mevalonate diphosphate decarboxylase (MDD) at Ser96
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 11001581
  • Author List

  • Larson-Casey JL; Murthy S; Ryan AJ; Brent Carter A
  • Start Page

  • 36204
  • End Page

  • 36219
  • Volume

  • 289
  • Issue

  • 52