Two cases of non-Hodgkin's lymphoma presenting as primary gynecologic malignancies.

Academic Article


  • BACKGROUND: Non-Hodgkin's lymphoma (NHL) presenting as a gynecologic malignancy is exceedingly rare. We present two cases of NHL presenting as primary ovarian and cervical cancer, respectively. CASE: A 66-year-old female presented with abdominal bloating and increased abdominal girth. She underwent a supracervical hysterectomy, bilateral salpingo-oophorectomy, and omentectomy for a large pelvic mass. Immunophenotyping/flow cytometry revealed monoclonal B-cells positive for the CD 20 marker, consistent with NHL. A 47-year-old female presented with persistent vaginal discharge and an ulcerative lesion of the cervix. Cervical biopsies were non-diagnostic for carcinoma but immunophenotyping demonstrated CD 20 positive B-cells, consistent with NHL. CONCLUSION: Although uncommon, lymphoma should be included in the differential diagnosis of gynecologic malignancies because of a favorable outcome when properly diagnosed and treated.
  • Published In


  • Aged, Diagnosis, Differential, Female, Humans, Immunophenotyping, Lymphoma, Non-Hodgkin, Middle Aged, Ovarian Neoplasms, Uterine Cervical Neoplasms
  • Digital Object Identifier (doi)

    Author List

  • Kendrick JE; Straughn JM
  • Start Page

  • 490
  • End Page

  • 492
  • Volume

  • 98
  • Issue

  • 3