A review of B7-H3 and B7-H4 immune molecules and their role in ovarian cancer

Academic Article

Abstract

  • A number of members of the B7 superfamily of ligands have been implicated in tumor immunogenicity and cancer development. Two of these recently characterized ligands, B7-H4 and B7-H3, have been linked to ovarian tumors. B7-H4 is consistently overexpressed in ovarian tumor specimens, and its tissue and serum levels have been found to be a potential biomarker for ovarian cancer, either alone or in combination with CA125. More recently, B7-H3 has been found to be overexpressed in a large series of ovarian cancer tumor specimens and similar to other types of carcinomas, B7-H3 overexpression has been correlated with poor survival. On the basis of the results obtained by knocking down B7-H3 protein using siRNA, researchers have suggested that blocking the action of B7-H3 could reduce tumor growth, metastatic potential, and improve survival. Because siRNA knock-down is not an ideal clinical therapeutic vehicle, additional studies using antibody-mediated suppression of the B7-H3 protein are necessary to fully evaluate the clinical potential of this molecule as a therapeutic target. © 2012 Elsevier Inc.
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    Digital Object Identifier (doi)

    Author List

  • Fauci JM; Straughn JM; Ferrone S; Buchsbaum DJ
  • Start Page

  • 420
  • End Page

  • 425
  • Volume

  • 127
  • Issue

  • 2