Executive function is associated with brain proton magnetic resonance spectroscopy in amnestic mild cognitive impairment

Academic Article


  • Persons with amnestic mild cognitive impairment (MCI) show deficits on executive function measures, although the neuroanatomic basis of executive function in MCI is unknown. We investigated cognitive correlates of 3-tesla proton magnetic resonance spectroscopy (MRS) of the posterior cingulate gyrus in 26 MCI patients. Posterior cingulate ratio of myo-inositol to creatine (mI/Cr) was negatively correlated (-.51) with spontaneous clock drawing. This relationship was not attenuated after accounting for age, overall cognitive function, or memory performance. This finding suggests a role for the posterior cingulate in executive function in MCI. Proton MRS may offer a means to track neurometabolic changes associated with cognitive impairment in MCI. © 2006 Psychology Press.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Griffith HR; Hollander JAD; Okonkwo O; Evanochko WT; Harrell LE; Zamrini EY; Brockington JC; Marson DC
  • Start Page

  • 599
  • End Page

  • 609
  • Volume

  • 29
  • Issue

  • 6