Progressive supranuclear palsy: Neuropathologic and clinical heterogeneity

Academic Article


  • To investigate potential heterogeneity in progressive supranuclear palsy (PSP), we examined 13 patients with neuropathologically diagnosed PSP. The clinical diagnosis ofPSP was made in eight of these individuals, whereas probable AD was the primary diagnosisin the remaining five. In addition to PSP neuropathology, seven of the 13 patients (54%) showed concomitant pathologic changes of Alzheimer's disease (AD), Parkinson's disease (PD), or both disorders. These observations indicate that AD and PD changes coexist with PSP neuropathology in a substantive proportion of patients and providefurther evidence of clinical and neuropathologic heterogeneity in neurodegenerative disorders. Moreover, our results suggest that PSP may be underdiagnosed and deserves more prominence in the differential diagnosis of dementing illness. © 1994 American Academy of Neurology.
  • Authors

    Published In

  • Neurology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Gearing M; Olson DA; Watts RL; Mirra SS
  • Start Page

  • 1015
  • End Page

  • 1024
  • Volume

  • 44
  • Issue

  • 6