Brain metabolic vorrelates of decision making in amnestic mild cognitive impairment

Academic Article


  • Persons with amnestic mild cognitive impairment (MCI) have subtle impairments in medical decision-making capacity (MDC). We examined the relationship between proton magnetic resonance spectroscopy (MRS) and MDC in MCI. Twenty-nine MCI patients and 42 controls underwent MRS to obtain ratios of N-acetylaspartate (NAA)/Creatine (Cr), Choline (Cho)/Cr, and myo-Inositol (mI)/Cr of the posterior cingulate. They also completed the Capacity to Consent to Treatment Instrument (CCTI), a vignette-based instrument measuring decisional standards of expressing choice, appreciating consequences of choice, providing rational reasons for choice, and understanding treatment choices. Patients showed abnormal MRS ratios of mI/Cr and Cho/Cr compared to controls, and impairments on the CCTI understanding and reasoning Standards. Performance on the reasoning standard of the CCTI was correlated with NAA/Cr (r =.46, p .05). The relationship of NAA/Cr with decision-making suggests a role for posterior cortical neuronal functioning in performance of complex IADLs in MCI. © 2010 Psychology Press.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Griffith HR; Okonkwo OC; Den Hollander JA; Belue K; Copeland J; Harrell LE; Brockington JC; Clark DG; Marson DC
  • Start Page

  • 492
  • End Page

  • 504
  • Volume

  • 17
  • Issue

  • 4