Subpopulations of CD4, CD8 thymocytes

Academic Article

Abstract

  • A population of highly purified CD4−, CD8− thymocytes was analyzed by both flow microfluorometry and in situ hybridization in an attempt to further elucidate thymocyte subpopulations. The double‐negative cells had a marked increase in expression of the c‐myb and T cell gamma genes relative to unseparated thymocytes. Approximately 27% were Ly‐24+, 8% Ly‐6C+ and 6% 6B2+. All of the Ly‐6C+ cells were also Ly‐24+. A small population (6%) of the CD4−, CD8− thymocytes had surface expression of the T cell receptor for antigen (F23.1); all were bright Ly‐1+ and half were Ly‐24+. These studies demonstrate that there are further subdivisions of the CD4−, CD8− thymocytes based upon cell surface expression of markers previously found on bone marrow cells and their non‐T cell progeny. Studies are in progress to determine whether these represent different stages of activation‐maturation or different lineages of cells. Copyright © 1987 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Gause WC; Mountz JD; Steinberg AD
  • Start Page

  • 1387
  • End Page

  • 1390
  • Volume

  • 17
  • Issue

  • 9