Application of a Fas ligand encoding a recombinant adenovirus vector for prolongation of transgene expression

Academic Article

Abstract

  • An adenovirus vector encoding murine Fas ligand (mFasL) under an inducible control was derived. In vivo ectopic expression of mFasL in murine livers induced an inflammatory cellular infiltration. Furthermore, ectopic expression of mFasL by myocytes did not allow prolonged vector-mediated transgene expression. Thus, ectopic expression of functional mFasL in vector- transduced cells does not appear to confer, by itself, an immunoprivileged site sufficient to mitigate adenovirus vector immunogenicity.
  • Published In

    Author List

  • Zhang HG; Bilbao G; Zhou T; Contreras JL; Gomez-Navarro J; Feng M; Saito I; Mountz JD; Curiel DT
  • Start Page

  • 2483
  • End Page

  • 2490
  • Volume

  • 72
  • Issue

  • 3