A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

Academic Article

Abstract

  • We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was at a nonsynonymous SNP, rs1143679 (P = 1.7 × 10-17, odds ratio = 1.78). We further replicated this association in two independent samples of individuals of African descent (P = 0.0002 and 0.003; overall meta-analysis P = 6.9 × 10 -22). The genetic association between ITGAM and SLE implicates the αMβ2-integrin adhesion pathway in disease development. © 2008 Nature Publishing Group.
  • Published In

  • Nature Genetics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Nath SK; Han S; Kim-Howard X; Kelly JA; Viswanathan P; Gilkeson GS; Chen W; Zhu C; McEver RP; Kimberly RP
  • Start Page

  • 152
  • End Page

  • 154
  • Volume

  • 40
  • Issue

  • 2