Epitope-Specific Regulation of Memory Programming by Differential Duration of Antigen Presentation to Influenza-Specific CD8+ T Cells

Academic Article

Abstract

  • Memory CD8 Tcells are programmed during the primary response for robust secondary responsiveness. Here we show that CD8 Tcells responding todifferent epitopes of influenza virus received qualitatively different signals during the primary response that altered their secondary responsiveness. Nucleoprotein (NP)-specific CD8 Tcells encountered antigen on CD40-licensed, CD70-expressing, CD103 CD11b dendritic cells (DCs) at later times in the primary response. As a consequence, they maintained CD25 expression and responded to interleukin-2 (IL-2) and CD27, which together programmed their robust secondary proliferative capacity and interferon-γ (IFN-γ)-producing ability. In contrast, polymerase (PA)-specific CD8 Tcells did not encounter antigen-bearing, CD40-activated DCs at later times in the primary response, did not receive CD27 and CD25 signals, and were not programmed to become memory CD8 Tcells with strong proliferative and cytokine-producing ability. As a result, CD8 Tcells responding to abundant antigens, like NP, dominated the secondary response. © 2014 Elsevier Inc. + + + - hi + + +
  • Published In

  • Immunity  Journal
  • Digital Object Identifier (doi)

    Author List

  • Ballesteros-Tato A; León B; Lee BO; Lund FE; Randall TD
  • Start Page

  • 127
  • End Page

  • 140
  • Volume

  • 41
  • Issue

  • 1