Although social problem-solving abilities have been consistently associated with indicators of behavioral health, this work has been largely confined to tests of specific theoretical issues. Research has yet to demonstrate how the separate elements of the social problem-solving model relate to different patterns of adjustment, particularly among persons who live with chronic disease. We studied the occurrence of different profiles of social problem-solving abilities observed among persons living with diabetes mellitus. We then examined differences between clusters on measures of life satisfaction and depression. Results indicate that distinct profiles in problem-solving abilities do occur and these groupings can be distinguished by their different patterns of adjustment. Implications for theoretical models of problem solving and clinical assessment and interventions for persons with diabetes are discussed.