The dual targeting of immunosuppressive cells and oxidants promotes effector and memory T-cell functions against lung cancer

Academic Article

Abstract

  • We have recently demonstrated that the combination of gemcitabine and a superoxide dismutase mimetic protects mice against lung cancer by suppressing the functions of myeloid-derived suppressor cells and by activating memory CD8+ T-cell responses. Persistent memory cells exhibited a glycolytic metabolism, which may have directly enhanced their effector functions. This combinatorial therapeutic regimen may reduce the propensity of some cancer patients to relapse. © 2014 Landes Bioscience.
  • Published In

  • OncoImmunology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Sawant A; Schafer CC; Ponnazhagan S; Deshane JS
  • Volume

  • 3
  • Issue

  • 1