Suppression of interferon production by vitamin A

Academic Article


  • Vitamin A (retinoic acid) suppressed interferon production by L cells infected with Newcastle disease virus (NDV). This suppression was maximal when cells were treated with retinoic acid for 2 hr after NDV adsorption, indicating that the inhibitory step was an early event. It was not due to inhibition of total RNA synthesis. Retinoic acid treatment caused both a delay in appearance of interferon and a reduced rate of synthesis thereafter.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Blalock JE; Gifford G
  • Start Page

  • 143
  • End Page

  • 147
  • Volume

  • 32
  • Issue

  • 1