Virus-induced corticosterone in hypophysectomized mice: A possible lymphoid adrenal axis

Academic Article


  • Infection of hypophysectomized mice with Newcastle disease virus caused a time-dependent increase in corticosterone and interferon production. Prior treatment with dexamethasone completely inhibited the virus-induced elevation in corticosterone concentration, but did not significantly alter the interferon response. Lymphocytes appear to be the most likely source of an adrenocorticotropin-like substance that is responsible for the increased corticosterone, since spleen cells from the virus-infected, but not from control or dexamethasone-treated, hypophysectomized mice showed positive immunofluorescence with antibody to adrenocorticotropin-(1-13 amide). Thus the adrenocorticotropin-like material and interferon appear to be coordinately induced and differentially controlled products of different genes. These findings strongly suggest the existence of a lymphoid-adrenal axis. Copyright © 1982 AAAS.
  • Authors

    Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Author List

  • Smith EM; Meyer WJ; Edwin Blalock J
  • Start Page

  • 1311
  • End Page

  • 1312
  • Volume

  • 218
  • Issue

  • 4579