Interferon Inducing Transformed Cell Surface Glycoproteins: Purification by Ia Antigen Affinity Chromatography

Academic Article


  • Ia antigens were previously shown to be B-cell receptors for transformed cell surface glycoproteins (TCSG). Ia antigen recognition of TCSG subsequently initiated interferon production. These findings have been exploited to highly purify TCSG from mouse L (H-2k) cells in one step by Ik antigen Sepharose affinity chromatography. These results point to the highly specific recognition of TCSG by Ia antigens and the B-cells on which they reside. The implications and applications of these Studies are discussed. © 1986, SAGE Publications. All rights reserved.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Hughes TK; Smith EM; Blalock JE
  • Start Page

  • 564
  • End Page

  • 567
  • Volume

  • 182
  • Issue

  • 4