The production of antibodies which recognize opiate receptors on murine leukocytes

Academic Article

Abstract

  • An antibody has been developed which recognizes opiate receptors on cells of the immune system. This antibody blocks specific binding of the radiolabeled opiate receptor ligand, 3H-dihydromorphine, to receptors on murine splenocytes. Additionally, the anti-receptor antibody competes with β-endorphin, met-enkephalin, and naloxone for the same binding site on the leukocytes. Moreover, the anti-receptor antibody possesses agonist activity similar to β-endorphin in suppressing cAMP production by lymphocytes. These results suggest the development of an antibody which recognizes classical opiate receptors on cells of the immune system. © 1988.
  • Authors

    Published In

  • Life Sciences  Journal
  • Digital Object Identifier (doi)

    Author List

  • Carr DJJ; Bost KL; Edwin Blalock J
  • Start Page

  • 2615
  • End Page

  • 2624
  • Volume

  • 42
  • Issue

  • 25