Evidence for a δ-class opioid receptor on cells of the immune system

Academic Article


  • Opioid receptors have been reported to be present on cells of the immune system. Both opioid receptor-ligand interactions which are reversible by naloxone (classical) and those interactions which are irreversible by naloxone (nonclassical) appear to alter various immunologic parameters through the ligand-receptor interactions. In an effort to characterize opioid receptors (which operate with classical interactions) on cells of the immune system, we employed the δ-class opioid receptor-specific ligand, cis-(+)-3-methylfentanylisothiocyanate (SUPERFIT). We herein report the specific labeling of a protein with a molecular weight of 70,000 Da under reducing conditions (58,000 Da under nonreducing conditions) from both B and T cell-enriched murine splenocytes and peripheral blood lymphocytes. Similar results are demonstrated by human peripheral blood lymphocytes and plastic-adherent (monocyte-enriched) leukocytes. © 1988.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Carr DJJ; Kim CH; deCosta B; Jacobson AE; Rice KC; Blalock JE
  • Start Page

  • 44
  • End Page

  • 51
  • Volume

  • 116
  • Issue

  • 1