Interleukin-2 induction of ACTH secretion: presence of an interleukin-2 receptor α-chain-like molecule on pituitary cells

Academic Article


  • Pituitary cells were shown to release corticotropin (ACTH) in response to interleukin-2 (IL-2) and to express a protein that is related to the α-chain of the IL-2 receptor (IL-2R). The α-chain-like molecule was bound by a rat monoclonal antibody to the murine IL-2 receptor as well as to IL-2. Sodium dodecylsulfate-polyacrylamide gel electrophoretic analysis of the affinity-purified material from pituitary cells demonstrated a protein which was similar to that which was isolated from activated splenocytes. Thus, IL-2 and its receptor may be one of several hormone-receptor pairs utilized by both the immune and neuroendocrine systems for intersystem communication. © 1989.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 15148185
  • Author List

  • Smith LR; Brown SL; Blalock JE
  • Start Page

  • 249
  • End Page

  • 254
  • Volume

  • 21
  • Issue

  • 2-3