Dimethyl sulfoxide inhibits phagocyte influx into infected pleural spaces and phagocyte locomotion in vitro

Academic Article


  • Influx of polymorphonuclear leukocytes (PMNs) and monocytes (MNs) into pleural spaces was decreased in dimethyl sulfoxide (DMSO)-treated rabbits infected intrapleurally with Staphylococcus aurem. In addition, pleural fluids contained S. aureus longer and marked pleural thickening with fibrosis occurred in DMSO-treated rabbits. DMSO also inhibited stimulated locomotion of PMN and MN in vitro, suggesting that the aforementioned responses in vivo may have occurred because of DMSO-mediated inhibition of the locomotion of PMN and MN. © 1983 Plenum Publishing Corporation.
  • Published In

  • Inflammation  Journal
  • Digital Object Identifier (doi)

    Author List

  • Antony VB; Sahn SA; Repine JE
  • Start Page

  • 377
  • End Page

  • 385
  • Volume

  • 7
  • Issue

  • 4