Effects of low-sodium, high-potassium dietary intake on cochlear lateral wall Na+,K+-ATPase

Academic Article


  • The effect of a low Na , high K diet on Na ,K -ATPase levels in cochlear lateral wall tissues was investigated in laboratory rats by using an enzyme-linked immunosorbent assay. The low Na , high K diet induced high aldosterone plasma levels in the animals as well as changes in plasma cation levels. Animals that received a low Na , high K diet demonstrated a statistically significant (97%) increase in Na ,K -ATPase levels in the stria vascularis when compared to animals that received a control diet. This increase in strial Na ,K -ATPase levels was blocked only 70% by administration of the aldosterone antagonist, spironolactone. Findings therefore indicate that strial Na ,K -ATPase may be modulated by both aldosterone and Na ,K plasma levels. Na ,K -ATPase levels in the spiral ligament were not affected by the experimental treatment. These findings suggest that spiral ligament Na ,K -ATPase levels may be regulated by factors other than aldosterone and Na ,K plasma levels. This study provides further insight into the mechanisms of the beneficial effects of salt restriction and potassium loading in patients with Méniére's disease. © 1994 Springer-Verlag. + + + + + + + + + + + + + + + + + + + + + +
  • Authors

    Digital Object Identifier (doi)

    Author List

  • ten Cate WJF; Curtis LM; Rarey KE
  • Start Page

  • 6
  • End Page

  • 11
  • Volume

  • 251
  • Issue

  • 1