Na+ + Cl--gradient-driven, high-affinity, uphill transport of taurine in human placental brush-border membrane vesicles

Academic Article

Abstract

  • Uptake of taurine in human placental brush-border membrane vesicles was greatly stimulated in the presence of an inwardly-directed Na+ + Cl--gradient and uphill transport of taurine could be demonstrated under these conditions. Na+ as well as Cl- were obligatory for this uptake and both ion gradients could energize the uphill transport. This Na+ + Cl--gradient-dependent taurine uptake was stimulated by an inside-negative membrane potential, demonstrating the electrogenicity of the process. The uptake system was highly specific for β-amino acids and the Km of the system for taurine was 6.5 ± 0.4 μM. © 1988.
  • Digital Object Identifier (doi)

    Author List

  • Miyamoto Y; Balkovetz DF; Leibach FH; Mahesh VB; Ganapathy V
  • Start Page

  • 263
  • End Page

  • 267
  • Volume

  • 231
  • Issue

  • 1