Duration of highly active antiretroviral therapy regimens

Academic Article


  • The median duration of highly active antiretroviral therapy (HAART) regimens was reported to be 11.8 months in one US study, but that study included both treatment-experienced and treatment-naive patients. The duration of initial HAART regimens for treatment-naive patients alone has not been reported. We selected 405 antiretroviral-naive patients who were seen at the University of Alabama at Birmingham HIV Outpatient Clinic from 1 January-1996 through 9 October 2001, and we assessed the duration of initial and successive HAART regimens in this group. Any antiretroviral medication change, excluding dosage changes, that lasted ≥14 days was considered to indicate the start of a new regimen. The median duration of regimens was determined by Kaplan-Meier analysis, and proportional hazards regression was used to identify factors associated with shorter duration of initial regimen. The median duration of initial regimens was 1.6 years, and medication toxicity-associated events were the cause of one-half of discontinuations. Only a history of opportunistic infection and injection drug use were significantly associated with shorter regimen duration.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 2635251
  • Author List

  • Chen RY; Westfall AO; Mugavero MJ; Cloud GA; Raper JL; Chatham AG; Acosta EP; Taylor KH; Carter J; Saag MS
  • Start Page

  • 714
  • End Page

  • 722
  • Volume

  • 37
  • Issue

  • 5