Chlamydial cervicitis and urethritis: Single dose treatment compared with doxycycline for seven days in community based practises

Academic Article


  • Study goal: To compare the efficacy and safety of single I g oral azithromycin with doxycycline, 100 mg twice daily for seven days for treatment of uncomplicated urogenital chlamydial infection. Study design: Randomised, unblinded, comparative trial, involving 597 patients demonstrating clinical evidence of genital chlamydia and a positive non-culture assay for Chlamydia trachomatis. Results: Among the azithromycin- and doxycycline-treated patients 61% and 60%, respectively, were asymptomatic within one week after the first dose. At two weeks, these figures increased to 86% and 83%, respectively. Bacteriological eradication, based on a negative assay, occurred in 338 (97%) of 347 azithromycin-treated patients and 161 (99%) of 163 doxycycline-treated patients. Conclusion: Treatment of uncomplicated chlamydial cervicitis and urethritis with single 1 g oral azithromycin is equivalent to standard therapy with doxycycline. Drug-related adverse events were approximately twice as common as previously reported for both drugs.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Thorpe EM; Stamm WE; Hook EW; Gall SA; Jones RB; Henry K; Whitworth G; Johnson RB
  • Start Page

  • 93
  • End Page

  • 97
  • Volume

  • 72
  • Issue

  • 2