Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients

Academic Article

Abstract

  • A pilot candidate gene association study was conducted to investigate the role of three common functional genetic polymorphisms of the low-affinity Fc gamma receptors, FCGR2A (131H/R), FCGR3A (158F/V) and FCGR3B (NA1/NA2) in Cryptococcus neoformans infections in individuals not infected with HIV. The FCGR2A 131RR and FCGR3A 158VV genotypes were over-represented [OR: 1.67 (1.05-2.63) and 2.04 (1.06-4.00), respectively] whereas the FCGR3B NA2NA2 was under-represented in patients with cryptococcosis (28% vs. 40% in controls). An analysis of haplotypes showed a significant difference in distribution between cases and controls overall and in Caucasians.
  • Published In

  • Medical Mycology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Meletiadis J; Walsh TJ; Choi EH; Pappas PG; Ennis D; Douglas J; Pankey GA; Larsen RA; Hamill RJ; Chanock S
  • Start Page

  • 513
  • End Page

  • 518
  • Volume

  • 45
  • Issue

  • 6