Treatment of blastomycosis with higher doses of fluconazole

Academic Article


  • Recent clinical data suggest that fluconazole at daily doses of 200 to 400 mg for at least 6 months is moderately effective therapy for non-life- threatening blastomycosis. To examine the usefulness of higher doses of fluconazole therapy for this disorder, we conducted a multicenter, randomized, open-label study to determine the efficacy and safety of two different daily doses of fluconazole (400 and 800 mg) in the treatment of non-life-threatening blastomycosis. Of 39 patients evaluable for efficacy analysis, 34 (87%) were successfully treated, including 89% and 85% of patients who received 400 and 800 mg, respectively. Five (83%) of six patients for whom prior antifungal therapy had failed were successfully treated. The mean duration of therapy was 8.9 months for successfully treated patients. Nineteen patients (48%) reported adverse events, although most were minor. We conclude that fluconazole at daily doses of 400 to 800 mg for at least 6 months is effective therapy for non-life-threatening blastomycosis.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Pappas PG; Bradsher RW; Kauffman CA; Cloud GA; Thomas CJ; Campbell GD; Chapman SW; Newman C; Dismukes WE
  • Start Page

  • 200
  • End Page

  • 205
  • Volume

  • 25
  • Issue

  • 2