Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts

Academic Article


  • The analysis of seven different age cohorts (697 individuals from 10 to 109 years old) revealed age-related changes in the 3'APOB-VNTR genotype pool. By recoding the 3'APOB-VNTR alleles into three size-classes (small, S, 26-34 repeats; medium, M, 35-39 repeats; large, L, 41-55 repeats), an age-related convex trajectory of the frequency of SS homozygotes was found. The frequency of SS in the genotype pool increased from the group aged 10-19 years (3.06 ± 1.74%) to that aged 40-49 years (8.51 ± 4.07%). Then it declined reaching the minimum value in centenarians (1.58 ± 0.90%). The observed trajectory is in agreement with that expected by assuming crossing of mortality curves relevant to subgroups of individuals having different genotypes.
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    Author List

  • De Benedictis G; Carotenuto L; Carrieri G; De Luca M; Falcone E; Rose G; Yashin AI; Bonafè M; Franceschi C
  • Start Page

  • 115
  • End Page

  • 122
  • Volume

  • 62
  • Issue

  • 2