HLA class I in three West African ethnic groups: Genetic distances from sub-Saharan and Caucasoid populations

Academic Article


  • Fulani of Burkina Faso (West Africa) are a particularly interesting ethnic group because of their lower susceptibility to Plasmodium falciparum malaria as compared to sympatric populations, Mossi and Rimaibé. Moreover, the occurrence of a Caucasoid component in their genetic makeup has been suggested on the basis of their physical traits and cultural traditions even though this view was not supported by genetic studies. A total of 149 unrelated subjects (53 Mossi, 47 Rimaibé and 49 Fulani) have been typed for 97 HLA class I alleles with the amplification refractory mutation system/polymerase chain reaction (ARMS/PCR) technique. Mossi and Rimaibé data were pooled since none of the 42 statistically testable alleles exhibited a significant heterogeneity. These pooled gene frequencies were found to be very different from those of Fulani: a certain (P<0.001) or a likely (0.001
  • Authors

    Published In

  • Tissue Antigens  Journal
  • Digital Object Identifier (doi)

    Author List

  • Modiano D; Luoni G; Petrarca V; Sodiomon Sirima B; De Luca M; Simporé J; Coluzzi M; Bodmer JG; Modiano G
  • Start Page

  • 128
  • End Page

  • 137
  • Volume

  • 57
  • Issue

  • 2