Objectives: To examine beliefs, prior use, and interest in using pharmacotherapy among people living with HIV/AIDS (PLWHA). Methods: Cross-sectional survey of smokers in a midwestern HIV clinic. Results: The sample (N = 146) included 69% men, 82% African Americans, 45% were in precontemplation for quitting, and 46% were interested in using pharmacotherapy. Primary reasons for non-use included cost and a belief that they would be able to quit on their own. Physician assistance was the strongest correlate of prior use. Perceived benefits and self-efficacy were the strongest correlates of willingness to use pharmacotherapy. Conclusions: Future interventions should address misconceptions, perceived benefits, and self-efficacy for using cessation aids. Physicians should offer pharmacotherapy to all smokers. Copyright (c) PNG Publications. All rights reserved.