Effects of atorvastatin and pravastatin on immune activation and T-cell function in antiretroviral therapy-suppressed HIV-1-infected patients

Academic Article

Abstract

  • © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins. This retrospective study was designed to assess statin effects on T-cell activation from HIV-infected individuals. Peripheral blood mononuclear cells fromantiretroviral therapy suppressed HIV-infected individuals receiving atorvastatin or pravastatin were evaluated for T-cell activation, exhaustion and function. Atorvastatin was associated with a significant reduction in CD8 T-cell activation (HLA-DR, CD38/HLA-DR) and exhaustion (TIM-3, TIM-3/PD-1) whereas pravastatin had no effect. In contrast, pravastatin increased antigen specific interferon γ production. These results suggest a differential effect of statins on immune activation and function.
  • Published In

  • AIDS  Journal
  • Digital Object Identifier (doi)

    Author List

  • Overton ET; Sterrett S; Westfall AO; Kahan SM; Burkholder G; Zajac AJ; Goepfert PA; Bansal A
  • Start Page

  • 2627
  • End Page

  • 2631
  • Volume

  • 28
  • Issue

  • 17